{ "_id": "6a4a35f2ebd24c958927082d", "Package": "dr4pl", "Type": "Package", "Date": "2021-08-16", "Title": "Dose Response Data Analysis using the 4 Parameter Logistic (4pl)\nModel", "Version": "2.0.0", "Authors@R": "c(person(\"Justin T.\", \"Landis\", role = c(\"aut\", \"cre\"), email = \"jtlandis314@gmail.com\"),\nperson(\"Alice\", \"Peng\", role = \"ctb\", email = \"alice98@live.unc.edu\"),\nperson(\"Hyowon\", \"An\", role = \"aut\", email = \"ahwbest@gmail.com\"),\nperson(\"Aubrey G.\", \"Bailey\", role = \"aut\", email = \"aubreybailey@gmail.com\"),\nperson(\"Dirk P.\", \"Dittmer\", role = \"aut\", email = \"dirk_dittmer@med.unc.edu\"),\nperson(\"James S.\", \"Marron\", role = \"aut\", email = \"marron@unc.edu\"))", "Description": "Models the relationship between dose levels and responses\nin a pharmacological experiment using the 4 Parameter Logistic\nmodel. Traditional packages on dose-response modelling such as\n'drc' and 'nplr' often draw errors due to convergence failure\nespecially when data have outliers or non-logistic shapes. This\npackage provides robust estimation methods that are less\naffected by outliers and other initialization methods that work\nwell for data lacking logistic shapes. We provide the bounds on\nthe parameters of the 4PL model that prevent parameter\nestimates from diverging or converging to zero and base their\njustification in a statistical principle. These methods are\nused as remedies to convergence failure problems. Gadagkar, S.\nR. and Call, G. B. (2015) \nRitz, C. and Baty, F. and Streibig, J. C. and Gerhard, D.\n(2015) .", "License": "GPL (>= 2)", "LazyData": "TRUE", "URL": "https://bitbucket.org/dittmerlab/dr4pl", "BugReports": "https://bitbucket.org/dittmerlab/dr4pl/issues?status=new&status=open", "RdMacros": "Rdpack", "RoxygenNote": "7.1.1", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "Repository": "https://jtlandis.r-universe.dev", "Date/Publication": "2022-07-25 16:37:18 UTC", "RemoteUrl": "https://bitbucket.org/dittmerlab/dr4pl", "RemoteRef": "HEAD", "RemoteSha": "61ee4c674011b7be06bdbbdb3cf921d9f7adbdbb", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-07 09:39:59 UTC", "User": "root" }, "Author": "Justin T. Landis [aut, cre],\nAlice Peng [ctb],\nHyowon An [aut],\nAubrey G. Bailey [aut],\nDirk P. Dittmer [aut],\nJames S. Marron [aut]", "Maintainer": "Justin T. 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